Neither the subjects nor the researchers knew who took the opioid blocker and who took a placebo on either day. On one day, the subjects were given a placebo sugar pill, and the other day the naltrexone. The study was a double-blind crossover using placebos with each subject tested twice. The researchers obtained objective and subjective pleasure readings for each subject listening to their chosen music before and after administering naltrexone. The 17 participants were allowed to bring two music tracks that “reliably produced intense feelings of pleasure for them, including but not limited to the sensation of chills.” They let the subjects pick their own music because emotional response is subjective.
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